The students, who were marching to demand the release of protesters arrested in recent days, massed in the east of the capital but the demonstration quickly became violent when they targeted the Tourism Ministry and riot police intervened.
They detained around 80 people, Manuel Quevedo, commander of the National Guard regiment in Caracas, told AFP.
Trucks carrying the detainees tried to move along the main route of the Caracas district of Chacao, heart of more than three months of opposition protests, amid a crowd shouting “Let them go!”
Last week more than 200 people were arrested in police raids on encampments of protesters in Caracas. Most have since been freed.
“Fewer and fewer people are heeding protest calls. Intimidation has succeeded,” one of the young marchers told AFP Wednesday, requesting anonymity after a previous arrest.
At least 42 people have died and more than 800 have been injured since students and other opponents of the socialist government took to the streets in February to protest rampant crime, runaway inflation and shortages of basic goods.