Seven people were killed in the northern Syrian town of Azaz when a truck filled with explosives blew up on Sunday, Turkish newspaper Sabah reported.
A number of others were wounded in the explosion, which no group immediately claimed responsibility for.
The Turkish backed Syrian rebel-held town is located across the border from Turkey.
Ankara has blamed a string of deadly car bomb attacks in the region, on the Syrian Kurdish People’s Protection Units (YPG), which Ankara views as a terrorist organisation due to its links to the Kurdish militants who have waged a decades-long insurgency inside Turkey.
Turkey, along with allied Syrian rebels, launched an offensive into northeast Syria targeting Kurdish forces that controlled the region in October of last year.
Clashes have continued in northern Syria between Kurdish and Turkish-backed forces despite Ankara’s deals with the United States and Russia to halt its military operation.