Instagram’s chief executive Kevin Systrom has said he and co-founder Mike Krieger are leaving the firm.
Mr Systrom, who heads the popular photo-sharing app launched in 2010, said they were taking some time off to “explore our curiosity and creativity”.
Instagram, which was purchased by Facebook in 2012 for $1bn (£76m), now has more than 1 billion users.
The departure comes amid reports of tension between Instagrams’ co-founders and Facebook’s leadership.
“We’re now ready for our next chapter,” Mr Systrom said in a statement.
“Building new things requires that we step back, understand what inspires us and match that with what the world needs; that’s what we plan to do.”
WhatsApp chief executive and co-founder Jan Koum said in April he would quit the popular messaging service he co-founded in 2009 and sold to Facebook in 2014.