The match finished 0-0 but pockets of rival fans were fighting inside the stadium more than 30 minutes after the final whistle.
Despite an increased security presence and a buffer zone between around 2,500 visiting fans and Marseille supporters, objects were thrown in both directions late in the first half.
Referee Pawel Raczkowski halted the match as some police then intervened to restore order.
Galatasaray coach Fatih Terim went over to his side’s fans to try and calm things down while Marseille captain Dimitri Payet did the same.
The match resumed with about eight minutes left in the first half with the sound of firecrackers still going off.
There were brief clashes between stewards and some Marseille fans early in the second half.
Moments before the final whistle Galatasaray forward Mbaye Diagne and Marseille defender William Saliba grabbed each other and jostled near the sideline.
Marseille was recently involved in fan violence during a French league game at Angers.
There was also serious disorder at the Nice-Marseille match last month. It was suspended and will be replayed next month.
In another match this month, fans threw ripped-up seats and tried to fight each other at halftime during the northern derby between Lens and Lille.
Turkish ultras often travel in large numbers. There were fights before the Paris Saint-Germain-Galatasaray game two seasons ago and when Lyon hosted Beşiktaş four years ago.
Hurrieyt Daily News