Yerepouni Daily News
No Result
View All Result
  • Հայերէն Լուրեր
  • Յօդուածներ
  • Հարցազրոյցներ
  • Մարզական
  • Այլազան
    • Զանազանք
    • Մշակութային
    • Գաղութահայ Կեանք
  • Արեւելահայերէն Լուրեր
  • English
    • World News
      • Africa
      • America
      • Asia
      • Australia
      • Europe
      • Middle East
    • Markets & Economy
    • International Press
    • Health
    • Social
    • Sports
    • Art & Entertainment
    • Science & Technology
  • أخبار باللغة العربية
  • Հայերէն Լուրեր
  • Յօդուածներ
  • Հարցազրոյցներ
  • Մարզական
  • Այլազան
    • Զանազանք
    • Մշակութային
    • Գաղութահայ Կեանք
  • Արեւելահայերէն Լուրեր
  • English
    • World News
      • Africa
      • America
      • Asia
      • Australia
      • Europe
      • Middle East
    • Markets & Economy
    • International Press
    • Health
    • Social
    • Sports
    • Art & Entertainment
    • Science & Technology
  • أخبار باللغة العربية
No Result
View All Result
Yerepouni Daily News
No Result
View All Result

Researcher shows novel drug significantly improves signs and symptoms of generalized pustular psoriasis

December 24, 2021
in Health
0
Researcher shows novel drug significantly improves signs and symptoms of generalized pustular psoriasis

by The Mount Sinai Hospital Credit: CC0 Public Domain Generalized pustular psoriasis (GPP) is a rare, life-threatening skin condition for which there are no approved treatments. It is characterized by episodes of widespread eruptions of painful, sterile pustules (blisters of non-infectious pus). There is a high unmet need for treatments that can rapidly and completely resolve the signs and symptoms of GPP flares. Flares greatly affect a person’s quality of life and can lead to hospitalization with serious complications, including heart failure, renal failure, sepsis, and death. A clinical trial has shown that spesolimab is a novel, humanized, selective antibody that blocks the activation of the interleukin-36 receptor (IL-36R), a signaling pathway within the immune system shown to be involved in the pathogeneses of several autoimmune diseases, including generalized pustular psoriasis. The novel drug demonstrated rapid clearance of pustules in adult patients with generalized pustular psoriasis (GPP) experiencing a flare. The study met the primary endpoint; 54% of patients had no visible pustules after a single dose of spesolimab, compared to 6% receiving a placebo at week one. The bottom line appears to be that spesolimab is rapidly effective in the majority of patients within one week of its first intravenous infusion for patients suffering from generalized pustular psoriasis. This is significant because generalized pustular psoriasis is a life-threatening condition that compromises the integrity of the skin. Patients are frequently hospitalized and often die from sepsis or other complications. The study’s senior author, Mark Lebwohl, MD, said, “Generalized pustular psoriasis is a rare life-threatening condition in which the protective functions of the skin are lost, leaving patients vulnerable to loss of electrolytes, nutrients, and fluids for the skin, causing high output cardiac failure, sepsis, and even death. Until now, other treatments used for this condition have not been reliably effective and are often too slow for a condition that is so dangerous. Spesolimab will hopefully be the first approved treatment in the United States for generalized pustular psoriasis, and we will finally have a reliable, rapidly effective treatment for this devastating disease.”

Medical Xpress

Previous Post

Immune memory less durable after severe COVID-19, study suggests

Next Post

No snow expected on New Year’s Day, say meteorologists

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

  • About Us
  • Contact Us

© 2021 Yerepouni News - Website by Alienative.net.

No Result
View All Result
  • Հայերէն Լուրեր
  • Յօդուածներ
  • Հարցազրոյցներ
  • Մարզական
  • Այլազան
    • Զանազանք
    • Մշակութային
    • Գաղութահայ Կեանք
  • Արեւելահայերէն Լուրեր
  • English
    • World News
      • Africa
      • America
      • Asia
      • Australia
      • Europe
      • Middle East
    • Markets & Economy
    • International Press
    • Health
    • Social
    • Sports
    • Art & Entertainment
    • Science & Technology
  • أخبار باللغة العربية

© 2021 Yerepouni News - Website by Alienative.net.